Starting six-month-old infants on solid food in the amounts recommended by standard feeding guides may lead to overfeeding, according to a study by scientists at the Johns Hopkins Bloomberg School of Public Health.
Solid food feeding guides are produced by infant formula makers, large children's hospitals and other infant health experts. They are meant to guide mothers and other caregivers in starting infants on solid food after initial exclusive milk and/or formula feeding. The study found evidence that recommendations in four feeding guides, if followed from age 6 to 12 months, would likely result in overfed, overweight infants.
"It is very important that children aren't overfed during infancy because we know that can lead to weight gain and related health problems later in life, yet the model used in our study showed that following current established guidelines could often lead to overfeeding of the infant," says study first author Dr Marie Ferguson, a research associate in the department of international health at the Bloomberg School.
The study was based on a model involving computer-simulated infants that were fed certain diets, and their resulting growth was recorded. The study also measured the computer-simulated infants' metabolic rates and activity levels, and documented body size and other attributes that were sampled from normal ranges and tracked day by day from age 6 months to 12 months. The simulation also modelled the fact that mothers normally adjust feeding amounts in response to infant weight gain or weight loss.
Testing the impacts of these feeding guides with real infants in a clinical trial would be a complex undertaking, the authors note, and would involve ethical issues given the risk of over- or under-feeding infants participating in such a trial.
The Virtual Infant computer-simulation model used for the study was developed by a team led by study senior author Dr Bruce Y Lee, an associate professor in the Bloomberg School's department of international health and executive director of the Global Obesity Prevention Centre. "It is important to pay closer attention to what infants are getting fed and how parents are being advised. Overfeeding an infant can make it much tougher for him or her to maintain a healthy weight in the future."
The researchers first validated their model by feeding their virtual infants according to a standard reference guide on infant energy requirements. They found that the resulting growth of the virtual infants was essentially in line with growth curves published by the World Health Organization and other authorities.
The team then simulated feeding of their virtual infants from age 6 to 12 months according to guides published by the Children's Hospital of Philadelphia, Johns Hopkins Medical Institutions, Enfamil and Similac. For every one of these guides, the researchers ran four simulations. Each modelled 1,000 infants, assumed standard breastmilk intake and assumed solid food intake according to the guide, but included a different rule about caregiver adjustments to solid food portions.
Ferguson and her colleagues found, in their initial analysis, that following each of the four guides for just a few months would drive the average body mass index (BMI) for the virtual infants into the "overweight" category – above the 85th percentile for BMIs. This finding applied even for the scenario in which solid food portions were kept to the lowest 25% (quartile) of the guide's recommended range.
The solid food feeding guide that seemed to produce the healthiest results was the Similac guide. In the most favourable scenario, with feeding portions kept to the lowest quartile, following the Similac guidelines did not move infants into the overweight category until age 10 months for girls and 11 months for boys.
Even when the team ran further simulations assuming that breast-milk portions were halved, all guides except Similac led to overweight BMIs between 9 and 11 months. The results, Ferguson says, suggest that although current standard solid food guidelines may have been based on the best available evidence, that evidence may not have been good enough.
"Our study shows what could happen when parents follow standard feeding guidelines and suggests that these guidelines may need to be revisited and revised," Ferguson says. "Feeding guidelines may also need to be adjusted and personalised to better match an individual infant's body type and metabolism."
Introduction: There are several recommendations advising caregivers when and how to introduce solid food to infants. These complementary feeding guides vary in terms of the recommendations for timing and portions. The objective of this study is to determine the impact of following different guidelines on weight trajectories of infants.
Methods: In 2018, the study team developed a computational simulation model to capture feeding behaviors, activity levels, metabolism, and body size of infants from 6 months to 1 year. Daily food intake of virtual infants based on feeding recommendations translated to changes in body weight. Next, simulations tested the impact of the following complementary feeding recommendations that provided amount, type, and timing of foods: Children's Hospital of Philadelphia, Johns Hopkins Medicine, Enfamil, and Similac.
Results: When virtual caregivers fed infants according to the four different guides, none of the simulated situations resulted in normal weight at 12 months when infants were also being breastfed along average observed patterns. Reducing breast milk portions in half while caregivers fed infants according to complementary feeding guidelines resulted in overweight BMIs between 9 and 11 months for Children's Hospital of Philadelphia, Johns Hopkins Medicine, and Enfamil guidelines. Cutting breast milk portions in half also led to infants reaching unhealthy underweight BMI percentiles between 7 and 11 months for female and male infants when caregivers followed Children's Hospital of Philadelphia, Johns Hopkins Medicine, and Similac guidelines.
Conclusions: This study identified situations in which infants could reach unhealthy weights, even while following complementary feeding guidelines, suggesting that current recommended portion sizes should be tightened.
Marie C Ferguson, Kelly J O'Shea, Lawrence D Hammer, Daniel L Hertenstein, Nathaniel J Schwartz, Lucas E Winch, Sheryl S Siegmund, Bruce Y Lee
[link url="https://www.jhsph.edu/news/news-releases/2019/current-guides-for-starting-infants-on-solid-food-may-lead-to-overfeeding.html"]Johns Hopkins Bloomberg School of Public Health material[/link]
[link url="https://www.ajpmonline.org/article/S0749-3797(19)30200-4/fulltext"]American Journal of Preventative Medicine abstract[/link]