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Doubled fat burn by exercising before breakfast

According to a small study, health scientists at the Universities of Bath and Birmingham found that by changing the timing of when you eat and exercise, people can better control their blood sugar levels. The six-week study, which involved thirty men classified as obese or overweight and compared results from two intervention groups (who ate breakfast before / after exercise) and a control group (who made no lifestyle changes), found that people who performed exercise before breakfast burned double the amount of fat than the group who exercised after breakfast.

They found that increased fat use is mainly due to lower insulin levels during exercise when people have fasted overnight, which means that they can use more of the fat from their fat tissue and the fat within their muscles as a fuel. To test proof-of-principle the initial study involved only men, but future studies will look to translate these findings for different groups including women.

Whilst this did not lead to any differences for weight loss over six weeks, it did have “profound and positive” effects on their health because their bodies were better able to respond to insulin, keeping blood sugar levels under control and potentially lowering the risk of diabetes and heart disease.

Building on emerging evidence that the timing of meals in relation to exercise can shift how effective exercise is, the team behind this study wanted to focus on the impact on the fat stores in muscles for individuals who either worked out before or after eating and the effect this had on insulin response to feeding.

Dr Javier Gonzalez of the department for health at the University of Bath explained: "Our results suggest that changing the timing of when you eat in relation to when you exercise can bring about profound and positive changes to your overall health.

"We found that the men in the study who exercised before breakfast burned double the amount of fat than the group who exercised after. Importantly, whilst this didn't have any effect on weight loss, it did dramatically improve their overall health.

"The group who exercised before breakfast increased their ability to respond to insulin, which is all the more remarkable given that both exercise groups lost a similar amount of weight and both gained a similar amount of fitness. The only difference was the timing of the food intake."

Over the six-week trial, the scientists found that the muscles from the group who exercised before breakfast were more responsive to insulin compared to the group who exercised after breakfast, in spite of identical training sessions and matched food intake. The muscles from those who exercised before breakfast also showed greater increases in key proteins, specifically those involved in transporting glucose from the bloodstream to the muscles.

For the insulin response to feeding after the 6-week study, remarkably, the group who exercised after breakfast were in fact no better than the control group.

Co-author Dr Gareth Wallis of the University of Birmingham added: "This work suggests that performing exercise in the overnight-fasted state can increase the health benefits of exercise for individuals, without changing the intensity, duration or perception of their effort. We now need to explore the longer-term effects of this type of exercise and whether women benefit in the same way as men."

The Physiological Society, The Rank Prize Funds, and The Allen Foundation funded this work.

Context: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness.
Objective: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization, and postprandial glucose metabolism.
Design: 1) Acute, randomised, crossover design (Acute Study); 2) 6-week, randomised, controlled design (Training Study).
Setting: General community.

Participants: Men with overweight/obesity (mean±SD, BMI: 30.2±3.5 kg.m-2 for Acute Study, 30.9±4.5 kg.m-2 for Training Study).
Interventions: Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion.

Results: Acute Study – exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study – postprandial glycemia was not differentially affected by 6-weeks of exercise training performed before versus after carbohydrate intake (p>0.05). However, postprandial insulinemia was reduced with exercise training performed before, but not after carbohydrate ingestion (p=0.03). This resulted in increased oral glucose insulin sensitivity (25±38 vs -21±32 mL.min-1.m-2; p=0.01), associated with increased lipid utilization during exercise (r=0.50, p=0.02). Regular exercise before nutrient provision also augmented remodelling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (p<0.05).
Conclusions: Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (in the fasted state) may exert beneficial effects on lipid utilisation and reduce postprandial insulinemia.

RM Edinburgh, HE Bradley, N-F Abdullah, SL Robinson, OJ Chrzanowski-Smith, JP Walhin, S Joanisse, KN Manolopoulos, A Philp, A Hengist, A Chabowski, FM Brodsky, F Koumanov, JA Betts, D Thompson, GA Wallis, JT Gonzalez

[link url="https://www.bath.ac.uk/announcements/increase-health-benefits-of-exercise-by-working-out-before-breakfast-new-research/"]University of Bath material[/link]

[link url="https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgz104/5599745"]Journal of Clinical Endocrinology & Endocrinology abstract[/link]

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