Brief psychological interventions delivered by lay counsellors in primary care were effective and cost-effective for patients with depression and harmful drinking in India, according to two studies by Vikram Patel of Harvard Medical School and colleagues from the London School of Hygiene & Tropical Medicine, London, UK and Sangath, India.
The authors have previously reported the effectiveness of the two interventions, Healthy Activity Programme (HAP) and Counselling for Alcohol Problems (CAP), at 3 months; however, the longer-term benefits of the interventions were previously unknown.
In the first trial, 493 adult primary health care attendees with moderately severe or severe depression were randomly assigned to either the HAP treatment plus enhanced usual care (EUC), or enhanced usual care (EUC) alone. The researchers found that HAP participants maintained the benefits they showed at the end of treatment through the 12-month period, with significantly lower symptom severity scores (adjusted mean difference in BDI-II: ?4.45) and higher rates of remission (PHQ-9 score < 5: 63% versus 48%) than participants who received EUC alone.
In the second trial, 377 adult male primary health care attendees with harmful drinking were randomly assigned to either the CAP treatment plus EUC, or EUC alone. The researchers found that CAP participants maintained the gains they showed at the end of treatment through the 12-month period, with higher remission rates (AUDIT score < 8: 54.3% versus 31.9%) and a greater proportion reporting no alcohol consumption in the past 14 days (45.1% versus 26.4%), compared with individuals who received EUC alone.
Both HAP and CAP were likely to be cost-effective, and could even save money if productivity costs were taken into account.
The authors say "We have provided the first evidence that two brief psychological therapies targeting the two leading mental health related causes of the global burden of disease, delivered by the same lay counsellor in routine primary care, to patients who had never received such therapies before, can lead to sustained improvements in health over one year, and that the investments made in providing this intervention is excellent value for money. Given the enormous economic and social consequences of untreated depression and harmful drinking, the moral imperative is for governments to scale up these treatments globally."
Background: The Healthy Activity Programme (HAP), a brief behavioural intervention delivered by lay counsellors, enhanced remission over 3 months among primary care attendees with depression in peri-urban and rural settings in India. We evaluated the sustainability of the effects after treatment termination, the cost-effectiveness of HAP over 12 months, and the effects of the hypothesized mediator of activation on clinical outcomes.
Methods and findings: Primary care attendees aged 18–65 years screened with moderately severe to severe depression on the Patient Health Questionnaire 9 (PHQ-9) were randomised to either HAP plus enhanced usual care (EUC) (n = 247) or EUC alone (n = 248), of whom 95% completed assessments at 3 months, and 91% at 12 months. Primary outcomes were severity on the Beck Depression Inventory–II (BDI-II) and remission on the PHQ-9. HAP participants maintained the gains they showed at the end of treatment through the 12-month follow-up (difference in mean BDI-II score between 3 and 12 months = −0.34; 95% CI −2.37, 1.69; p = 0.74), with lower symptom severity scores than participants who received EUC alone (adjusted mean difference in BDI-II score = −4.45; 95% CI −7.26, −1.63; p = 0.002) and higher rates of remission (adjusted prevalence ratio [aPR] = 1.36; 95% CI 1.15, 1.61; p < 0.009). They also fared better on most secondary outcomes, including recovery (aPR = 1.98; 95% CI 1.29, 3.03; p = 0.002), any response over time (aPR = 1.45; 95% CI 1.27, 1.66; p < 0.001), higher likelihood of reporting a minimal clinically important difference (aPR = 1.42; 95% CI 1.17, 1.71; p < 0.001), and lower likelihood of reporting suicidal behaviour (aPR = 0.71; 95% CI 0.51, 1.01; p = 0.06). HAP plus EUC also had a marginal effect on WHO Disability Assessment Schedule score at 12 months (aPR = −1.58; 95% CI −3.33, 0.17; p = 0.08); other outcomes (days unable to work, intimate partner violence toward females) did not statistically significantly differ between the two arms. Economic analyses indicated that HAP plus EUC was dominant over EUC alone, with lower costs and better outcomes; uncertainty analysis showed that from this health system perspective there was a 95% chance of HAP being cost-effective, given a willingness to pay threshold of Intl$16,060—equivalent to GDP per capita in Goa—per quality-adjusted life year gained. Patient-reported behavioural activation level at 3 months mediated the effect of the HAP intervention on the 12-month depression score (β = −2.62; 95% CI −3.28, −1.97; p < 0.001). Serious adverse events were infrequent, and prevalence was similar by arm. We were unable to assess possible episodes of remission and relapse that may have occurred between our outcome assessment time points of 3 and 12 months after randomisation. We did not account for or evaluate the effect of mediators other than behavioural activation.
Conclusions: HAP’s superiority over EUC at the end of treatment was largely stable over time and was mediated by patient activation. HAP provides better outcomes at lower costs from a perspective covering publicly funded healthcare services and productivity impacts on patients and their families.
Benedict Weobong, Helen A Weiss, David McDaid, Daisy R Singla, Steven D Hollon, Abhijit Nadkarni, A-La Park, Bhargav Bhat, Basavraj Katti, Arpita Anand, Sona Dimidjian, Ricardo Araya, Michael King, Lakshmi Vijayakumar, G Terence Wilson, Richard Velleman, Betty R Kirkwood, Christopher G Fairburn, Vikram Patel
[link url="https://www.sciencedaily.com/releases/2017/09/170912154855.htm"]PLOS material[/link]
[link url="http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002385"]PLOS Medicine abstract[/link]