Researchers at the University of Birmingham and King's College London have found that staying active slows the physical manifestations of ageing.
The researchers set out to assess the health of older adults who had exercised most of their adult lives to see if this could slow down ageing. The study recruited 125 amateur cyclists aged 55 to 79, 84 of which were male and 41 were female. The men had to be able to cycle 100 km in under 6.5 hours, while the women had to be able to cycle 60 km in 5.5 hours. Smokers, heavy drinkers and those with high blood pressure or other health conditions were excluded from the study.
The participants underwent a series of tests in the laboratory and were compared to a group of adults who do not partake in regular physical activity. This group consisted of 75 healthy people aged 57 to 80 and 55 healthy young adults aged 20 to 36.
The study showed that loss of muscle mass and strength did not occur in those who exercise regularly. The cyclists also did not increase their body fat or cholesterol levels with age and the men's testosterone levels also remained high, suggesting that they may have avoided most of the male menopause.
More surprisingly, the study also revealed that the benefits of exercise extend beyond muscle as the cyclists also had an immune system that did not seem to have aged either.
An organ called the thymus, which makes immune cells called T cells, starts to shrink from the age of 20 and makes less T cells. In this study, however, the cyclists' thymuses were making as many T cells as those of a young person.
The findings come as figures show that less than half of over 65s do enough exercise to stay healthy and more than half of those aged over 65 suffer from at least two diseases.* Professor Janet Lord, director of the Institute of Inflammation and Ageing at the University of Birmingham, said: "Hippocrates in 400 BC said that exercise is man's best medicine, but his message has been lost over time and we are an increasingly sedentary society.
"However, importantly, our findings debunk the assumption that ageing automatically makes us more frail. Our research means we now have strong evidence that encouraging people to commit to regular exercise throughout their lives is a viable solution to the problem that we are living longer but not healthier."
Dr Niharika Arora Duggal, also of the University of Birmingham, said: "We hope these findings prevent the danger that, as a society, we accept that old age and disease are normal bedfellows and that the third age of man is something to be endured and not enjoyed."
Professor Stephen Harridge, director of the Centre of Human & Aerospace Physiological Sciences at King's College London, said: "The findings emphasise the fact that the cyclists do not exercise because they are healthy, but that they are healthy because they have been exercising for such a large proportion of their lives. Their bodies have been allowed to age optimally, free from the problems usually caused by inactivity. Remove the activity and their health would likely deteriorate."
Norman Lazarus, Emeritus Professor at King's College London and also a master cyclist and Dr Ross Pollock, who undertook the muscle study, both agreed that: "Most of us who exercise have nowhere near the physiological capacities of elite athletes. We exercise mainly to enjoy ourselves. Nearly everybody can partake in an exercise that is in keeping with their own physiological capabilities. Find an exercise that you enjoy in whatever environment that suits you and make a habit of physical activity. You will reap the rewards in later life by enjoying an independent and productive old age."
The researchers hope to continue to assess the cyclists to see if they continue to cycle and stay young.
In this study, results are reported from the analyses of vastus lateralis muscle biopsy samples obtained from a subset (n = 90) of 125 previously phenotyped, highly active male and female cyclists aged 55–79 years in regard to age. We then subsequently attempted to uncover associations between the findings in muscle and in vivo physiological functions. Muscle fibre type and composition (ATPase histochemistry), size (morphometry), capillary density (immunohistochemistry) and mitochondrial protein content (Western blot) in relation to age were determined in the biopsy specimens. Aside from an age-related change in capillary density in males (r = −.299; p = .02), no other parameter measured in the muscle samples showed an association with age. However, in males type I fibres and capillarity (p < .05) were significantly associated with training volume, maximal oxygen uptake, oxygen uptake kinetics and ventilatory threshold. In females, the only association observed was between capillarity and training volume (p < .05). In males, both type II fibre proportion and area (p < .05) were associated with peak power during sprint cycling and with maximal rate of torque development during a maximal voluntary isometric contraction. Mitochondrial protein content was not associated with any cardiorespiratory parameter in either males or females (p > .05). We conclude in this highly active cohort, selected to mitigate most of the effects of inactivity, that there is little evidence of age-related changes in the properties of VL muscle across the age range studied. By contrast, some of these muscle characteristics were correlated with in vivo physiological indices.
Ross D Pollock, Katie A O'Brien, Lorna J Daniels, Kathrine B Nielsen, Anthea Rowlerson, Niharika A Duggal, Norman R Lazarus, Janet M Lord, Andrew Philp, Stephen DR Harridge
It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (55–79 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age-matched older adults and 55 young adults not involved in regular exercise. The frequency of naïve T cells and recent thymic emigrants (RTE) were both higher in cyclists compared with inactive elders, and RTE frequency in cyclists was no different to young adults. Compared with their less active counterparts, the cyclists had significantly higher serum levels of the thymoprotective cytokine IL-7 and lower IL-6, which promotes thymic atrophy. Cyclists also showed additional evidence of reduced immunesenescence, namely lower Th17 polarization and higher B regulatory cell frequency than inactive elders. Physical activity did not protect against all aspects of immunesenescence: CD28−veCD57+ve senescent CD8 T-cell frequency did not differ between cyclists and inactive elders. We conclude that many features of immunesenescence may be driven by reduced physical activity with age.
Niharika Arora Duggal, Ross D Pollock, Norman R Lazarus, Stephen Harridge, Janet M Lord
[link url="https://www.birmingham.ac.uk/news/latest/2018/03/regular-exercise-slows-down-ageing.aspx"]University of Birmingham material[/link]
[link url="http://onlinelibrary.wiley.com/doi/10.1111/acel.12735/abstract"]Aging Cell abstract 1[/link]
[link url="http://onlinelibrary.wiley.com/doi/10.1111/acel.12750/full"]Aging Cell abstract 2[/link]