Tuesday, September 26, 2023
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New HCV treatment guidelines

The European Association for the Study of the Liver (EASL) has released its latest hepatitis C treatment guidelines. The guidelines recommend a variety of interferon-free direct-acting antiviral (DAA) regimens for people with hepatitis C virus genotypes 1-6. The panel offered recommendations for patient groups that remain difficult to treat, such as those with decompensated cirrhosis, but noted that more research is still needed in several areas.

Also, EASL and the Latin American Association for the Study of the Liver released joint guidelines for non-invasive assessment of liver disease severity, noting that liver stiffness measurement is becoming the standard of care.

"Virtually everyone infected has a right to be treated for hepatitis C, but we have to acknowledge reality – the new drugs are too expensive and the huge number of patients make it impossible to treat everyone in the next couple years, so we have to prioritise accordingly," said EASL guidelines panel co-ordinator Jean-Michel Pawlotsky.

The guidelines are intended to assist physicians and other healthcare providers, as well as people with hepatitis C and other interested individuals, in clinical decision-making. The new recommendations apply to therapies that have been approved in the EU, but they are written broadly enough that new drugs can be considered as they become available, EASL vice secretary Laurent Castera said. Hepatitis C therapy has been a "very rapidly moving field," he said, "but our impression is that the field is stabilising" – with overall SVR rates above 90% – and is now moving to address "niche" populations like people with decompensated cirrhosis, liver transplant recipients, and patients with chronic kidney disease.

[link url="http://www.aidsmap.com/page/2965042/"]Aidsmap material[/link]
[link url="http://www.journal-of-hepatology.eu/article/S0168-8278(15)00208-1/abstract"]EASL guidelines[/link]
[link url="http://www.easl.eu/research/our-contributions/clinical-practice-guidelines/detail/recommendations-on-treatment-of-hepatitis-c-2015"]EASL guidelines[/link]

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