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Stress in pregnancy may affect baby's sex, risk of preterm birth

Stress during pregnancy may affect baby’s sex and increase the risk of a pre-term birth. "The womb is an influential first home, as important as the one a child is raised in, if not more so," says study leader Dr Catherine Monk, professor of medical psychology at Columbia University Vagelos College of Physicians and Surgeons and director of women's mental health in the department of obstetrics & gynaecology at New York-Presbyterian/Columbia University Irving Medical Centre.

Because stress can manifest in a variety of ways, both as a subjective experience and in physical and lifestyle measurements, Monk and her colleagues examined 27 indicators of psychosocial, physical, and lifestyle stress collected from questionnaires, diaries, and daily physical assessments of 187 otherwise healthy pregnant women, ages 18 to 45.

About 17% (32) of the women were psychologically stressed, with clinically meaningful high levels of depression, anxiety, and perceived stress. Another 16% (30) were physically stressed, with relatively higher daily blood pressure and greater caloric intake compared with other healthy pregnant women. The majority (nearly 67%, or 125) were healthy.

The study suggested that pregnant women experiencing physical and psychological stress are less likely to have a boy. On average, around 105 males are born for every 100 female births. But in this study, the sex ratio in the physically and psychologically stressed groups favoured girls, with male-to-female ratios of 4:9 and 2:3, respectively.

"Other researchers have seen this pattern after social upheavals, such as the 9/11 terrorist attacks in New York City, after which the relative number of male births decreased," says Monk. "This stress in women is likely of long-standing nature; studies have shown that males are more vulnerable to adverse prenatal environments, suggesting that highly stressed women may be less likely to give birth to a male due to the loss of prior male pregnancies, often without even knowing they were pregnant."

Physically stressed mothers, with higher blood pressure and caloric intake, were more likely to give birth prematurely than unstressed mothers.

Among physically stressed mothers, foetuses had reduced heart rate-movement coupling – an indicator of slower central nervous system development – compared with unstressed mothers. Psychologically stressed mothers had more birth complications than physically stressed mothers.

The researchers also found that what most differentiated the three groups was the amount of social support a mother received from friends and family. For example, the more social support a mother received, the greater the likelihood of her having a male baby.

When social support was statistically equalized across the groups, the stress effects on preterm birth disappeared. "Screening for depression and anxiety are gradually becoming a routine part of prenatal practice," says Monk. "But while our study was small, the results suggest enhancing social support is potentially an effective target for clinical intervention."

An estimated 30% of pregnant women report psychosocial stress from job strain or related to depression and anxiety, according to the researchers. Such stress has been associated with increased risk of premature birth, which is linked to higher rates of infant mortality and of physical and mental disorders, such as attention-deficit hyperactivity disorder and anxiety, among offspring.

How a mother's mental state might specifically affect a foetus was not examined in the study. "We know from animal studies that exposure to high levels of stress can raise levels of stress hormones like cortisol in the uterus, which in turn can affect the foetus," says Monk. "Stress can also affect the mother's immune system, leading to changes that affect neurological and behavioural development in the foetus. What's clear from our study is that maternal mental health matters, not only for the mother but also for her future child."

Abstract
Maternal prenatal stress influences offspring neurodevelopment and birth outcomes including the ratio of males to females born; however, there is limited understanding of what types of stress matter, and for whom. Using a data-driven approach with 27 variables from questionnaires, ambulatory diaries, and physical assessments collected early in the singleton pregnancies of 187 women, 3 latent profiles of maternal prenatal stress emerged that were differentially associated with sex at birth, birth outcomes, and fetal neurodevelopment. Most women (66.8%) were in the healthy group (HG); 17.1% were in the psychologically stressed group (PSYG), evidencing clinically meaningful elevations in perceived stress, depression, and anxiety; and 16% were in the physically stressed group (PHSG) with relatively higher ambulatory blood pressure and increased caloric intake. The population normative male:female secondary sex ratio (105:100) was lower in the PSYG (2:3) and PHSG (4:9), and higher in the HG (23:18), consistent with research showing diminished male births in maternal stress contexts. PHSG versus HG infants were born 1.5 wk earlier (P < 0.05) with 22% compared to 5% born preterm. PHSG versus HG fetuses had decreased fetal heart rate–movement coupling (P < 0.05), which may indicate slower central nervous system development, and PSYG versus PHSG fetuses had more birth complications, consistent with previous findings among offspring of women with psychiatric illness. Social support most strongly differentiated the HG, PSYG, and PHSG groups, and higher social support was associated with increased odds of male versus female births. Stress phenotypes in pregnant women are associated with male vulnerability and poor fetal outcomes.

Authors
Kate Walsh, Clare A McCormack, Rachel Webster, Anita Pinto, Seonjoo Lee, Tianshu Feng, H Sloan Krakovsky, Sinclaire M O’Grady, Benjamin Tycko, Frances A Champagne, Elizabeth A Werner, Grace Liu, Catherine Monk

[link url="https://www.cuimc.columbia.edu/news/stress-during-pregnancy-may-affect-babys-sex-risk-preterm-birth"]Columbia University material[/link]

[link url="https://www.pnas.org/content/early/2019/10/08/1905890116"]PNAS abstract[/link]

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