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Unpacking COVID vaccination's effect on fertility and sexual functioning

Rumours and myths about the COVID-19 vaccine effects on reproduction and sexual functioning have spread across social media platforms, where people swop rumours of erectile dysfunction and fertility disruptions after vaccination, writes Scientific American.

Yet studies so far have not linked the vaccines with problems related to pregnancy, menstrual cycles, erectile performance or sperm quality. The evidence does, however, show that COVID-19 can involve problems in all of these areas.

Health officials have tried to ease concerns by explaining that data from clinical trials and hundreds of millions of vaccinations support the safety of the shots. Scientific American spoke to four experts in reproductive and sexual biology about pervasive myths, the evidence against them and the real damage to health caused by COVID-19, and has published a number of conclusions that can be drawn from studies of vaccinated people and those who have had the disease.

Vaccination is not associated with adverse effects in pregnancy. COVID-19 is the real threat

The US Centers for Disease Control and Prevention updated its recommendations in early August, strengthening its advice that people who are pregnant or breastfeeding should be vaccinated against COVID-19.

The UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) found this month that “there is no pattern … to suggest that any of the COVID-19 vaccines used in the UK increase the risk of congenital anomalies or birth complications. Pregnant women have reported similar suspected reactions to the vaccines as people who are not pregnant.”

If infected with the virus, pregnant women are at highly increased risk for severe disease and complications from COVID-19, compared with their same-age counterparts, says Tara Shirazian, an associate professor and a gynecologist at NYU Langone Health.

The immune system effects of pregnancy itself make an infection about five times more likely, says Jane Frederick, a reproductive endocrinology and fertility specialist and medical director of HRC Fertility in California. “You get infected more quickly, and pregnant women can go downhill fast,” she adds.

People should take the opportunity to get vaccinated before conceiving, but the vaccine is safe across all three trimesters of pregnancy, says Mary Rosser, director of integrated women’s health at the Department of Obstetrics & Gynecology at Columbia University Irving Medical Center. In early August, 22 medical groups released a joint statement saying that “the best way for pregnant individuals to protect themselves against the potential harm from COVID-19 infection is to be vaccinated”.

The vaccines show no fertility effects, including among people using assisted reproductive techniques. One origin of fertility falsehoods about the vaccines may be a letter co-written by a former Pfizer researcher and sent to the European Medicines Agency (EMA) in December 2020. The two authors asked that all vaccine studies be suspended. They claimed that vaccine-induced antibodies against a protein that SARS-CoV-2 uses to enter human cells might also attack another human protein needed for embryo implantation. SARS-CoV-2 is the virus that causes COVID.

A study published in June 2021 compared the success of transferring embryos to women who carried antibodies to SARS-CoV-2 after vaccination or infection to success rates among those without antibodies. The presence of antibodies did not appear to affect such rates during 171 transfer attempts.

In a New York Times essay, a pair of immunologists described their work showing that the sequences of amino acids that make up the implantation-related protein and those that make up the virus spike protein are not similar and that spike-targeting antibodies do not cross-react with the implantation protein.

Stress may be responsible for menstrual cycle problems after vaccination

Some vaccinated women have reported disruptions to their monthly cycle. “We are not dismissing them,” Rosser says. “What they say about their own bodies is important, and they know their bodies best.”
But nothing in the vaccines is a likely candidate to explain these complaints. Experts agree that a probable indirect factor is stress. Getting a new vaccine is itself stressful, Shirazian says, and many kinds of stressors can throw off a menstrual cycle. The physiological effects of these tensions might disrupt pathways that drive menstrual timing.

The good news, Rosser says, is that any menstrual effects appear to be transient. “I’ve talked to enough women in the past eight months, and it seems as though whatever it is, it’s short-lived,” she says.

In early August EMA released a report noting that no cause-and-effect association had been established between complaints of menstrual disruptions and COVID-19 vaccination. Separately, MHRA found no link between menstrual disorders and COVID vaccines.

Some descriptions of menstrual problems mention clotting during heavier periods. Shirazian says that the term “blood clot” as it relates to menstrual flow is different from the term used medically to describe a clot in a blood vessel. “They have nothing to do with each other,” she says. The clotting of menstrual blood happens as the blood exits the vessels and is not a risk for blocking flow to tissues.

COVID-19 may affect the menstrual cycle

Becoming ill with COVID is associated with clotting in the medical sense—producing pulmonary embolisms that block blood flow to the lungs, for instance. Some evidence also points to the effects of SARS-CoV-2 on menstrual cycles. A small study of 177 patients who had COVID-19, published in September 2020, showed that 28% experienced cycle disruptions, including less bleeding and a longer cycle.

Infectious diseases themselves also are a stressor, Rosser says. “Illness causes stress,” she adds. And next to any menstrual cycle disruptions that might follow vaccination, “it’s 100 percent worse to have COVID, if you had to choose between the two,” Shirazian says.

Vaccines do not threaten sperm or erectile function, but COVID-19 does

Ranjith Ramasamy, director of reproductive urology at the University of Miami, has published several studies describing the novel coronavirus in penile and testicular tissue and its effects on erectile dysfunction. He and his colleagues also looked at the potential effects of vaccines in these areas and found none.

To Ramasamy, the most unsurprising observation was how COVID-19 interferes with erections, which rely on blood flow. “COVID affects the blood vessels that supply organs, and the penis is not much different from other organs that require a lot of blood,” he says. What was more surprising was the presence of SARS-CoV-2 in penile tissue even nine months after an infection. These results were from a small study of people with penile implants because of severe erectile dysfunction. The rich blood supply to the penis seems to have ensured a route for the virus to these tissues, Ramasamy says.

Like many viruses, SARS-CoV-2 also finds its way into the testes, where it can enter cells and cause damage. A biopsy study of testis tissue from six people who died of COVID-19 showed the virus still lingering in a sample from one of the patients and decreased sperm counts in another three. A sample from a patient who had survived the disease also showed persistent SARS-CoV-2 in the testes.

Ramasamy and his colleagues have found no detrimental changes in sperm counts and other fertility measures after vaccination. “One of the biggest myths with the vaccine was that it could affect fertility,” he says, and finding no negative effect on sperm counts “was very reassuring.”

Some last words on vaccination and the ill effects of COVID-19

All of the experts had the same take-home message: the key to protecting against the reproductive and sexual effects of COVID-19 is to get vaccinated.

 

Scientific American article – COVID Vaccines Show No Signs of Harming Fertility or Sexual Function (Open access)

 

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